Pre-implantation genetic testing (PGT) is a way of detecting the genetic and chromosomal abnormalities in the embryo before transferring it into the uterine cavity. The use of this method allows identifying embryos with chromosomal disorders or helps to prevent transmission of inherited diseases to the child.
Pre-implantation genetic testing is divided into several categories:
PGT – A (Preimplantation genetic testing for aneuploidy)
The method helps to detect pathological chromosomal rearrangements in the embryo, even before its transfer into the uterine cavity. This reduces the likelihood of termination of pregnancy, increases the chance of successful pregnancy and the birth of a healthy baby. This method is recommended for patients with a history of malnutrition, with many unsuccessful attempts of IVF, for patients at the older age.
PGT – M (Pre-implantation genetic testing for monogenic (single-gene) disorders)
This method is used to identify monogenic diseases that can be inherited from their parents. Recommended when there is a high risk of transmission of an inherited mutation to the unborn baby. For example, when one partner has an autosomal dominant disease state, or both partners are carriers of the autosomal recessive condition of the same disease. Also used to diagnose gender-related diseases.